Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications
Hydrogels are a unique class of polymeric materials that possess an interconnected porous network across various length scales from nano- to macroscopic dimensions and exhibit remarkable structure-derived properties, including high surface area, an accommodating matrix, inherent flexibility, control...
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| Published in | Chemical Society reviews Vol. 49; no. 2; pp. 433 - 464 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
21.01.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Hydrogels are a unique class of polymeric materials that possess an interconnected porous network across various length scales from nano- to macroscopic dimensions and exhibit remarkable structure-derived properties, including high surface area, an accommodating matrix, inherent flexibility, controllable mechanical strength, and excellent biocompatibility. Strong and robust adhesion between hydrogels and substrates is highly desirable for their integration into and subsequent performance in biomedical devices and systems. However, the adhesive behavior of hydrogels is severely weakened by the large amount of water that interacts with the adhesive groups reducing the interfacial interactions. The challenges of developing tough hydrogel-solid interfaces and robust bonding in wet conditions are analogous to the adhesion problems solved by marine organisms. Inspired by mussel adhesion, a variety of catechol-functionalized adhesive hydrogels have been developed, opening a door for the design of multi-functional platforms. This review is structured to give a comprehensive overview of adhesive hydrogels starting with the fundamental challenges of underwater adhesion, followed by synthetic approaches and fabrication techniques, as well as characterization methods, and finally their practical applications in tissue repair and regeneration, antifouling and antimicrobial applications, drug delivery, and cell encapsulation and delivery. Insights on these topics will provide rational guidelines for using nature's blueprints to develop hydrogel materials with advanced functionalities and uncompromised adhesive properties.
This review presents insights into the fundamental challenges of wet adhesion, and the applications of catechol-functionalized hydrogels in diverse areas. |
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| Bibliography: | Prof. Boxin Zhao is a full professor in chemical engineering at the University of Waterloo in Canada. He obtained his PhD in Chemical Engineering from the McMaster University in 2004, worked as a postdoc at UCSB in 2005-2008. He has 100+ peer-refereed papers on the top journals including Macromolecules, Advanced Materials, Nature Materials, and Progress in Polymer Sciences. He was awarded a prestigious Fulbright Visiting Research Chair at UCSB in 2015. The current research interests of his group are in the areas of smart polymers, hydrogels, bionanomaterials, soft materials, surface science, biomimetic adhesion and robotic devices, advanced manufacturing, etc. Prof. Bruce P. Lee received a PhD degree in biomedical engineering from Northwestern University. Prior to his current appointment at Michigan Technological University, he co-founded a startup company, Nerites Corporation, which aimed at commercializing adhesives and coating inspired by mussel adhesive proteins. He joined the Department of Biomedical Engineering at Michigan Technological University in 2011. His current research interests lie in utilizing the interfacial chemistries of mussel adhesive proteins in designing bioadhesives and smart materials. He was awarded the 2016 Young Investigator Award from the Office of Naval Research. Prof. Sun is a distinguished professor, and also the Dean of the School of MSE at SEU. He has the experience of over 20 years working in Austria, Japan and USA. His research interests cover the research and development of metallic materials, intermetallic compounds, ceramics and composites. In the past decade, he devoted most of his energy to the MAX phase materials, a family of ternary compounds, and their derivatives, MXenes, an emerging new family of 2D materials. He has authored over 200 SCI indexed papers and applied over 40 patents. Dr Wei Zhang is an associate professor in School of Material Science and Engineering at Southeast University. He obtained his MASc in Chemistry and PhD in Nanotechnology from University of Waterloo. Since joining Southeast University in 2016, he has established the Surface Science and Bionanomaterials Laboratory, working on both fundamental and applied research to meet the growing need of nanotechnologies in advanced materials, e.g., multifunctional and smart hydrogels and aerogels, flexible energy storage devices or electronic packaging. He was awarded the Periodic Table of Younger Chemists in 2019 from the Chinese Chemical Society. Qiang Zhao is a professor at the School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China. He graduated from the Department of Polymer Science and Engineering, Zhejiang University, China, under the supervision of Prof. J. W. Qian. Then he worked as a post-doc at Zhejiang University (with Prof. C. J. Gao), MPIKG (with Prof. J. Yuan and Prof. M. Antonietti), and UCSB (with Prof. J. H. Waite). His research interests center on polyelectrolytes, separation membranes, wet adhesives and biomimetic polymers. He has authored 75 publications in these areas of research. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c9cs00285e |