Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan

• Published in: Frontiers in immunology Vol. 15; p. 1337520
• Main Authors: Zhao, Tianchen, Tani, Yuta, Makino-Okamura, Chieko, Takita, Morihito, Yamamoto, Chika, Kawahara, Eiki, Abe, Toshiki, Sugiura, Sota, Yoshimura, Hiroki, Uchiyama, Taiga, Yamazaki, Isato, Ishigame, Harumichi, Ueno, Takaharu, Okuma, Kazu, Wakui, Masatoshi, Fukuyama, Hidehiro, Tsubokura, Masaharu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.03.2024
• Subjects: antibody waning; bivalent vaccination; Immunology; mRNA vaccination vulnerable population; SARS-CoV2; vaccination; bivalent vaccination; SARS-CoV2; antibody waning; mRNA vaccination vulnerable population; vaccination

This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the...