Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan

This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the...

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Published inFrontiers in immunology Vol. 15; p. 1337520
Main Authors Zhao, Tianchen, Tani, Yuta, Makino-Okamura, Chieko, Takita, Morihito, Yamamoto, Chika, Kawahara, Eiki, Abe, Toshiki, Sugiura, Sota, Yoshimura, Hiroki, Uchiyama, Taiga, Yamazaki, Isato, Ishigame, Harumichi, Ueno, Takaharu, Okuma, Kazu, Wakui, Masatoshi, Fukuyama, Hidehiro, Tsubokura, Masaharu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.03.2024
Subjects
antibody waning
bivalent vaccination
Immunology
mRNA vaccination vulnerable population
SARS-CoV2
vaccination
bivalent vaccination
SARS-CoV2
antibody waning
mRNA vaccination vulnerable population
vaccination
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Summary:This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the XBB 1.5 strain, individuals with comorbidities showed reduced responses. The study suggests the need for continuous vaccine updates to address emerging SARS-CoV-2 variants and highlights the importance of monitoring real-world immune responses.
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Reviewed by: Ebony Gary, Wistar Institute, United States
These authors have contributed equally to this work
Sabrina Helmold Hait, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH), United States
Edited by: Firzan Nainu, Hasanuddin University, Indonesia
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1337520