Regeneratory Characteristics of Complex Extract and Isolated Diterpene Alkaloids of Aconitum baikalense

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 4; pp. 439 - 443
• Main Authors: Nesterova, Yu. V., Povetieva, T. N., Suslov, N. I., Zhdanov, V. V., Hrichkova, T. Yu, Udut, E. V., Chaykovskiy, A. S., Gaydamovich, N. N., Andreeva, T. I., Dygai, A. M.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2012; Springer; Springer Nature B.V
• Subjects: Aconitine - analogs & derivatives; Aconitine - isolation & purification; Aconitine - pharmacology; Aconitum - chemistry; Alkaloids; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Proliferation - drug effects; Cells, Cultured; Colony-Forming Units Assay; Female; Fibroblasts - cytology; Fibroblasts - drug effects; Internal Medicine; Laboratory Medicine; Mice; Mice, Inbred CBA; Pathology; Pharmacology and Toxicology; Plant Components, Aerial - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Regeneration - drug effects; Regeneration - physiology; Skin; Skin - drug effects; Wound Healing - drug effects; Wound Healing - physiology; fibroblast precursors; plane skin wound; regeneration; diterpene alkaloids
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1548-4

The effects of complex extract from Aconitum baikalense on reparative regeneration of a plane dorsal skin wound were studied. Treatment with Aconitum baikalense tincture stimulated reparation and skin regeneration. The effects of the Aconitum baikalense alkaloids on functional activity of fibroblast precursors were studied in vitro by cultural methods. Mesaconitine, hypaconitine, songorine, napelline, and 12-epinapelline N-oxide significantly stimulated the growth of colonies from fibroblast precursors. This indicated direct stimulation of fibroblasts by aconite alkaloids, which could be a mechanism of reparative activity of the complex extract.