miR-146b-5p inhibits glioma migration and invasion by targeting MMP16

• Published in: Cancer letters Vol. 339; no. 2; pp. 260 - 269
• Main Authors: Li, Yanyan, Wang, Ying, Yu, Lin, Sun, Cuiyun, Cheng, Degang, Yu, Shizhu, Wang, Qian, Yan, Yaping, Kang, Chunsheng, Jin, Shumei, An, Tongling, Shi, Cuijuan, Xu, Jinling, Wei, Changjuan, Liu, Jing, Sun, Jing, Wen, Yanjun, Zhao, Shujun, Kong, Yanling
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.10.2013; Elsevier Limited
• Subjects: Base Sequence; Brain cancer; Brain research; Cancer; Cell Line, Tumor; cell movement; Cell Movement - genetics; Chromosome Deletion; Chromosomes; Chromosomes, Human, Pair 10; Gelatinases - metabolism; Gene Expression; Gene Knockdown Techniques; gene overexpression; Glioma - genetics; Glioma - pathology; Gliomas; Hematology, Oncology and Palliative Medicine; Humans; Invasion; Matrix Metalloproteinase 16 - chemistry; Matrix Metalloproteinase 16 - genetics; Matrix Metalloproteinase 16 - metabolism; MicroRNAs - chemistry; MicroRNAs - genetics; MicroRNAs - metabolism; Migration; miR-146b-5p; MMP16; Neoplasm Invasiveness; pancreatic neoplasms; prostatic neoplasms; R&D; Research & development; Science; Tumors; miR-146b-5p; MMP16; Gliomas; Migration; Invasion
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2013.06.018

Highlights • We find miR-146b-5p decreases in glioma tissues and is negatively correlated with MMP16 expression. • We find the loss of chromosome 10q cause miR-146b-5p decreases in glioma tissues. • We find miR-146b-5p inhibits the migration and invasion of glioblastoma cell lines via targeting MMP16 mRNA.