Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster

One or two monovalent vaccine boosters showed a large decrease in neutralization activity against omicron subvariants. The BA.5-containing bivalent booster improved neutralizing activity against all omicron subvariants.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 388; no. 2; pp. 183 - 185
Main Authors Davis-Gardner, Meredith E., Lai, Lilin, Wali, Bushra, Samaha, Hady, Solis, Daniel, Lee, Matthew, Porter-Morrison, Andrea, Hentenaar, Ian T., Yamamoto, Fumiko, Godbole, Sucheta, Liu, Yuan, Douek, Daniel C., Lee, Frances Eun-Hyung, Rouphael, Nadine, Moreno, Alberto, Pinsky, Benjamin A., Suthar, Mehul S.
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 12.01.2023
Subjects
Antibodies
Coronavirus
Coronaviruses
Correspondence
COVID-19 vaccines
Health sciences
Hypothesis testing
Immunization
Infectious Disease
mRNA
Mutation
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral Infections
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Summary:One or two monovalent vaccine boosters showed a large decrease in neutralization activity against omicron subvariants. The BA.5-containing bivalent booster improved neutralizing activity against all omicron subvariants.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2214293