Hydrogen-rich saline protects against ultraviolet B radiation injury in rats

• Published in: Journal of biomedical research Vol. 26; no. 5; pp. 365 - 371
• Main Authors: Guo, Ze, Zhou, Bingrong, Li, Wei, Sun, Xuejun, Luo, Dan
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.09.2012; Editorial Department of Journal of Biomedical Research
• Subjects: hydrogen-rich saline; oxidative stress; photo-damage; Research Paper; skin; ultraviolet B; 保护作用; 富氢; 活性氧物种; 生理盐水; 皮肤损伤; 紫外线B; 超氧化物歧化酶; 辐射损伤; skin; hydrogen-rich saline; ultraviolet B; photo-damage; oxidative stress
• ISSN: 1674-8301
• DOI: 10.7555/jbr.26.20110037

Exposure of skin to solar ultraviolet（UV） radiation induces photo-damage.Ultraviolet B（UVB） is the major component of UV radiation which induces the production of reactive oxygen species（ROS） and plays an impor-tant role in photo-damage.Hydrogen gas reduces ROS and alleviates inflammation.In this study,we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation.UVB radiation was irradiated on female C57BL/6 rats to induce skin injury.Hydrogen-rich saline and nitrogen-rich saline were ad-ministered to rats by intraperitoneal injection.Skin damage was detected by microscope after injury.UVB radia-tion had a significant affection in tumor necrosis factor alpha,interleukin（IL）-1β and IL-6 levels,tissue superox-ide dismutase,malondialdehyde and nitric oxide activity.Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury.Hydrogen-rich saline protected against UVB radiation injury,possibly by reducing inflammation and oxidative stress.