Emerging Families of Ion Channels Involved in Urinary Bladder Nociception

The expression of multiple ion channels and receptors is essential for nociceptors to detect noxious stimuli of a thermal, mechanical or chemical nature. The peripheral sensory transduction systems of the urinary bladder include sensory nerve endings, urothelial cells and others whose location is su...

Full description

Saved in:
Bibliographic Details
Published inPharmaceuticals Vol. 3; no. 7; pp. 2248 - 2267
Main Authors Araki, Isao, Yoshiyama, Mitsuharu, Kobayashi, Hideki, Mochizuki, Tsutomu, Du, Shuqi, Okada, Yusaku, Takeda, Masayuki
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 19.07.2010
MDPI
Subjects
ion channel
nociception
Review
sensation
transient receptor potential
urinary bladder
nociception
sensation
ion channel
urinary bladder
transient receptor potential
Online AccessGet full text

Cover

More Information
Summary:The expression of multiple ion channels and receptors is essential for nociceptors to detect noxious stimuli of a thermal, mechanical or chemical nature. The peripheral sensory transduction systems of the urinary bladder include sensory nerve endings, urothelial cells and others whose location is suitable for transducing mechanical and chemical stimuli. There is an increasing body of evidence implicating the Deg/ENaC and TRP channel families in the control of bladder afferent excitability under physiological and pathological conditions. Pharmacological interventions targeting these ion channels may provide a new strategy for the treatment of pathological bladder sensation and pain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1424-8247
1424-8247
DOI:10.3390/ph3072248