Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: An early indicator of morbidity and mortality

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 119; no. 1; pp. 155 - 162
• Main Authors: Munoz, Ricardo, Laussen, Peter C., Palacio, Guillermo, Zienko, Lynne, Piercey, Gary, Wessel, David L.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.01.2000; AATS/WTSA; Elsevier
• Subjects: Adolescent; Adult; Biological and medical sciences; Cardiology. Vascular system; Cardiopulmonary Bypass; Child; Child, Preschool; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Female; Heart; Heart Defects, Congenital - blood; Heart Defects, Congenital - surgery; Humans; Infant; Infant, Newborn; Lactic Acid - blood; Male; Medical sciences; Postoperative Complications - blood; Postoperative Complications - diagnosis; Predictive Value of Tests; Prospective Studies; Regression Analysis; Risk Factors; ROC Curve; Statistics, Nonparametric; Treatment Outcome; Human; Prognosis; Congenital; Mortality; Cardiovascular disease; Congenital disease; Morbidity; Cardiopulmonary bypass; Lactates; Treatment; Heart disease; Surgery; Anesthesia; Bibliographic review
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/S0022-5223(00)70231-5

Objective: Our objective was to evaluate the change in lactate level during cardiopulmonary bypass and the possible predictive value in identifying patients at high risk of morbidity and mortality after surgery for congenital cardiac disease. Methods: We prospectively studied lactate levels in 174 nonconsecutive patients undergoing cardiopulmonary bypass during operations for congenital cardiac disease. Arterial blood samples were taken before cardiopulmonary bypass, during cardiopulmonary bypass (cooling and rewarming), after cardiopulmonary bypass, and during admission to the cardiac intensive care unit. Complicated outcomes were defined as open sternum as a response to cardiopulmonary instability, renal failure, cardiac arrest and resuscitation, extracorporeal membrane oxygenation, and death. Results: The largest increment in lactate level occurred during cardiopulmonary bypass. Lactate levels decreased between the postbypass period and on admission to the intensive care unit. Patients who had circulatory arrest exhibited higher lactate levels at all time points. Nonsurvivors had higher lactate levels at all time points. A change in lactate level of more than 3 mmol/L during cardiopulmonary bypass had the optimal sensitivity (82%) and specificity (80%) for mortality, although the positive predictive value was low. Conclusions: Hyperlactatemia occurs during cardiopulmonary bypass in patients undergoing operations for congenital cardiac disease and may be an early indicator for postoperative morbidity and mortality. (J Thorac Cardiovasc Surg 2000;119:155-62)