High-content analysis of cancer genome DNA alterations
New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes ( BRAF , EGFR , and PIK3CA ) in multiple cancer typ...
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| Published in | Current opinion in genetics & development Vol. 18; no. 1; pp. 68 - 72 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2008
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| Subjects | |
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| Abstract | New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes ( BRAF , EGFR , and PIK3CA ) in multiple cancer types: preliminary insight into the entire repertoire of genes that can be mutated in cancer; the discovery of new oncogenes by high-resolution profiling of DNA copy number alterations; and the bioinformatic-driven discovery of oncogenic gene fusions. High-content promoter methylation detection systems have been used to discover additional methylated genes and have provided evidence for a stem cell origin for certain tumors. Some of these advances have had significant impact on the development and clinical testing of new therapeutics. |
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| AbstractList | New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes ( BRAF , EGFR , and PIK3CA ) in multiple cancer types: preliminary insight into the entire repertoire of genes that can be mutated in cancer; the discovery of new oncogenes by high-resolution profiling of DNA copy number alterations; and the bioinformatic-driven discovery of oncogenic gene fusions. High-content promoter methylation detection systems have been used to discover additional methylated genes and have provided evidence for a stem cell origin for certain tumors. Some of these advances have had significant impact on the development and clinical testing of new therapeutics. New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes ( BRAF, EGFR, and PIK3CA) in multiple cancer types: preliminary insight into the entire repertoire of genes that can be mutated in cancer; the discovery of new oncogenes by high-resolution profiling of DNA copy number alterations; and the bioinformatic-driven discovery of oncogenic gene fusions. High-content promoter methylation detection systems have been used to discover additional methylated genes and have provided evidence for a stem cell origin for certain tumors. Some of these advances have had significant impact on the development and clinical testing of new therapeutics. New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes ( BRAF, EGFR, PIK3CA ) in multiple cancer types; preliminary insight into the entire repertoire of genes that can be mutated in cancer; the discovery of new oncogenes by high-resolution profiling of DNA copy number alterations; and the bioinformatic-driven discovery of oncogenic gene fusions. High-content promoter methylation detection systems have been used to discover additional methylated genes and have provided evidence for a stem cell origin for certain tumors. Some of these advances have had significant impact on the development and clinical testing of new therapeutics. |
| Author | Lucito, Robert McCombie, Richard W Powers, Scott Wooster, Richard Degenhardt, Yan Y |
| AuthorAffiliation | 1 Translational Medicine, GlaxoSmithKline, King of Prussia, PA, 19406, USA 2 Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, NY, 11797, USA |
| AuthorAffiliation_xml | – name: 2 Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, NY, 11797, USA – name: 1 Translational Medicine, GlaxoSmithKline, King of Prussia, PA, 19406, USA |
| Author_xml | – sequence: 1 fullname: Degenhardt, Yan Y – sequence: 2 fullname: Wooster, Richard – sequence: 3 fullname: McCombie, Richard W – sequence: 4 fullname: Lucito, Robert – sequence: 5 fullname: Powers, Scott |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18339543$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1039_C1MD00194A crossref_primary_10_1111_j_1747_0285_2008_00697_x crossref_primary_10_1016_j_mrfmmm_2014_07_007 crossref_primary_10_1556_ABiol_63_2012_4_7 crossref_primary_10_1016_j_phrs_2009_12_011 crossref_primary_10_1371_journal_pone_0028503 crossref_primary_10_1016_j_bbcan_2009_03_001 |
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| SubjectTerms | DNA Mutational Analysis DNA, Neoplasm - chemistry Epigenesis, Genetic Gene Dosage Genes, Neoplasm Genome, Human Humans Medical Education Neoplasms - genetics Oncogene Proteins, Fusion - genetics Translocation, Genetic |
| Title | High-content analysis of cancer genome DNA alterations |
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