Combatting antibiotic-resistant bacteria using nanomaterials
The dramatic increase in antimicrobial resistance for pathogenic bacteria constitutes a key threat to human health. The Centers for Disease Control and Prevention has recently stated that the world is on the verge of entering the "post-antibiotic era", one where more people will die from b...
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| Published in | Chemical Society reviews Vol. 48; no. 2; pp. 415 - 427 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
21.01.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The dramatic increase in antimicrobial resistance for pathogenic bacteria constitutes a key threat to human health. The Centers for Disease Control and Prevention has recently stated that the world is on the verge of entering the "post-antibiotic era", one where more people will die from bacterial infections than from cancer. Recently, nanoparticles (NPs) have emerged as new tools that can be used to combat deadly bacterial infections. Nanoparticle-based strategies can overcome the barriers faced by traditional antimicrobials, including antibiotic resistance. In this tutorial review, we have highlighted multiple nanoparticle-based approaches to eliminate bacterial infections, providing crucial insight into the design of elements that play critical roles in creating antimicrobial nanotherapeutics. In particular, we have focused on the pivotal role played by NP-surface functionality in designing nanomaterials as self-therapeutic agents and delivery vehicles for antimicrobial cargo.
Nanomaterials as self-therapeutic agents and drug-delivery vehicles for antimicrobial therapies. |
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| Bibliography: | Cheng-Hsuan Li received his bachelor and master in chemistry from Chung Yuan Christian University and National Tsing Hua University, respectively. He is currently a graduate student under the supervision of Prof. Vincent M. Rotello. His research focus on incorporating phytochemicals into nanomaterials for antimicrobial use. Irshad Hussain received his MSc (Chemistry) from Quaid-i-Azam University, Islamabad, and PhD in Chemistry (Nanomaterials) from the University of Liverpool, UK, in 2005. Currently, he is Associate Professor in Department of Chemistry & Chemical Engineering, SBA School of Science & Engineering, LUMS, Lahore. His research interests include the applications of metal/metal oxide nanoparticles in biomedical sciences and renewable energy technologies. Shazia Mumtaz received her MPhil from University of Sargodha and PhD from the Department of Chemistry & Chemical Engineering, SBA School of Science & Engineering, LUMS, Lahore, Pakistan, in 2018. Currently, she is Assistant Professor in Higher Education Department (HED), Punjab, Pakistan. Her research interests include the use of inorganic nanomaterials for the sensing and killing of bacteria. Vincent Rotello is Goessmann Professor of Chemistry and Distinguished University Professor at the University of Massachusetts-Amherst. He joined the University of Massachusetts in 1993, receiving the NSF CAREER, Cottrell Scholar and Camille Dreyfus Teacher-Scholar awards, the Sloan Fellowship, and the Langmuir Lectureship, and is a Fellow of the AAAS and the Royal Society of Chemistry (UK). He is the Editor-in-Chief of Bioconjugate Chemistry, and on the Editorial Board of 14 other journals. His research program focuses on engineering the interface between hard and soft materials for applications in nanotechnology and nanomedicine. Akash Gupta received his Integrated MSc in Chemistry from IIT (ISM), Dhanbad, India in 2013. Currently, he is a graduate student in the Department of Chemistry at the University of Massachusetts, Amherst under the supervision of Professor Vincent M. Rotello. His current research focuses on designing engineered nanomaterials for imaging and therapy of bacteria and biofilm-associated infections. |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c7cs00748e |