Molecular targets for tendon neoformation

Tendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces generated by muscle contraction into movements of the joints, whereas ligaments con...

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Published inThe Journal of clinical investigation Vol. 118; no. 2; pp. 439 - 444
Main Authors Aslan, Hadi, Kimelman-Bleich, Nadav, Pelled, Gadi, Gazit, Dan
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.02.2008
Subjects
Animals
Biomarkers - metabolism
Biomedical research
Care and treatment
Cell Line
Complications and side effects
Connective tissue
Connective tissues
Gene expression
Humans
Inflammation
Injuries
Ligaments
Mice
Morphogenesis
Musculoskeletal system
Physiological aspects
Regeneration
Review Series
Tendinitis
Tendon injuries
Tendon Injuries - metabolism
Tendons
Tendons - embryology
Tendons - physiology
United States
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Summary:Tendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces generated by muscle contraction into movements of the joints, whereas ligaments connect bone to bone and provide joint stabilization. Unfortunately, the almost acellular and collagen I-rich structure of tendons and ligaments makes them very poorly regenerating tissues. Injured tendons and ligaments are considered a major clinical challenge in orthopedic and sports medicine. This Review discusses the several factors that might serve as molecular targets that upon activation can enhance or lead to tendon neoformation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI33944