TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway

Highlights ► TRPM7 overexpression is correlated to cancer metastasis and invasive breast cancers. ► Knockdown of TRPM7 suppresses MDA-MB-435 breast cancer cell migration and invasion. ► TRPM7 mediates migration and invasion of MDA-MB-435 breast cancer cell through the MAPK pathway.

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Bibliographic Details
Published inCancer letters Vol. 333; no. 1; pp. 96 - 102
Main Authors Meng, Xiaojing, Cai, Chunqing, Wu, Jiguo, Cai, Shaoxi, Ye, Changsheng, Chen, Haiyang, Yang, Zhengduo, Zeng, Hongqiang, Shen, Qiang, Zou, Fei
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.06.2013
Elsevier Limited
Subjects
Breast cancer
breast neoplasms
Breast Neoplasms - pathology
Cell adhesion & migration
Cell Line, Tumor
Cell Movement
Female
Hematology, Oncology and Palliative Medicine
Humans
Invasion
Kinases
MAP Kinase Signaling System - physiology
MAPK
metastasis
Neoplasm Invasiveness
Phosphatidylinositol 3-Kinases - physiology
phosphorylation
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt - physiology
RNA interference
RNA, Small Interfering - genetics
Signal transduction
Src
TRPM Cation Channels - physiology
TRPM7
TRPM7
Breast cancer
MAPK
Src
Invasion
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Summary:Highlights ► TRPM7 overexpression is correlated to cancer metastasis and invasive breast cancers. ► Knockdown of TRPM7 suppresses MDA-MB-435 breast cancer cell migration and invasion. ► TRPM7 mediates migration and invasion of MDA-MB-435 breast cancer cell through the MAPK pathway.
Bibliography:http://dx.doi.org/10.1016/j.canlet.2013.01.031
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.031