YEATS2 is a selective histone crotonylation reader

Dear Editor, Histone lysine crotonylation （Kcr） is a recently identified non-acetyl acylation conserved from yeast to human. We have previously shown that histone Kcr marked active chromatin and was enriched at promoter and enhancer regions [1]. Different from the histone ly- sine acetylation （Kac）,...

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Bibliographic Details
Published inCell research Vol. 26; no. 5; pp. 629 - 632
Main Authors Zhao, Dan, Guan, Haipeng, Zhao, Shuai, Mi, Wenyi, Wen, Hong, Li, Yuanyuan, Zhao, Yingming, Allis, C David, Shi, Xiaobing, Li, Haitao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2016
Nature Publishing Group
Subjects
631/45/612/100/2285
631/57/2272
Animals
Biomedical and Life Sciences
Cell Biology
Crotonates - chemistry
Crotonates - metabolism
Histones - chemistry
Histones - metabolism
Humans
Letter to the Editor
Life Sciences
Protein Domains
Protein Processing, Post-Translational - physiology
Transcription Factors - chemistry
Transcription Factors - metabolism
减数分裂
启动子
基因失活
染色质
火车站
监管机制
组蛋白乙酰化
读者
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Summary:Dear Editor, Histone lysine crotonylation （Kcr） is a recently identified non-acetyl acylation conserved from yeast to human. We have previously shown that histone Kcr marked active chromatin and was enriched at promoter and enhancer regions [1]. Different from the histone ly- sine acetylation （Kac）, histone Kcr preferentially marks ＂escapee genes＂ during post-meiotic gene inactivation, suggesting a unique regulatory mechanism centered on Kcr independent of Kac [2]. Nevertheless, in contrast to the histone Kac readers that are well documented,
Bibliography:31-1568
Dear Editor, Histone lysine crotonylation （Kcr） is a recently identified non-acetyl acylation conserved from yeast to human. We have previously shown that histone Kcr marked active chromatin and was enriched at promoter and enhancer regions [1]. Different from the histone ly- sine acetylation （Kac）, histone Kcr preferentially marks ＂escapee genes＂ during post-meiotic gene inactivation, suggesting a unique regulatory mechanism centered on Kcr independent of Kac [2]. Nevertheless, in contrast to the histone Kac readers that are well documented
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ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2016.49