Relationship between Antitumor Effect of Polysaccharides and Biogenic Amines in Tumor Tissues

Relationship between the host-mediated antitumor effect and biogenic amines was investigated. Histamine and serotonin values in solid tumor of sarcoma 180 were periodically determined by fluorometric method. When treated with the antitumor active polysaccharide (EA5), significantly high histamine va...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 23; no. 9; pp. 2148 - 2150
Main Authors IKEKAWA, TETSURO, SANO, MITSUAKI, OKABE, MIDORI, FUKUOKA, FUMIKO
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1975
Japan Science and Technology Agency
Subjects
Animals
Antineoplastic Agents - pharmacology
Biogenic Amines - metabolism
Histamine - metabolism
Mice
Mice, Inbred ICR
Polysaccharides - pharmacology
Sarcoma 180 - metabolism
Serotonin - metabolism
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Summary:Relationship between the host-mediated antitumor effect and biogenic amines was investigated. Histamine and serotonin values in solid tumor of sarcoma 180 were periodically determined by fluorometric method. When treated with the antitumor active polysaccharide (EA5), significantly high histamine values were detected at the end of 2 weeks after tumor transplantation. Although some increase of the histamine value was also found at 2 and 3 weeks by treatment with the antitumor inactive polysaccharide (EA505) and/or cyclic adenosine monophosphate it was not significant in comparison with the remarkable increase in the antitumor active polysaccharide (EA5) treatment. Any remarkable increase of serotonin values in tumor tissues was not found.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.23.2148