An Outbreak of Multidrug-Resistant Tuberculosis among Hospitalized Patients with the Acquired Immunodeficiency Syndrome

• Published in: The New England journal of medicine Vol. 326; no. 23; pp. 1514 - 1521
• Main Authors: Edlin, Brian R, Tokars, Jerome I, Grieco, Michael H, Crawford, Jack T, Williams, Julie, Sordillo, Emelia M, Ong, Kenneth R, Kilburn, James O, Dooley, Samuel W, Castro, Kenneth G, Jarvis, William R, Holmberg, Scott D
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 04.06.1992
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - complications; Adult; AIDS; AIDS/HIV; Air Movements; Biological and medical sciences; Case-Control Studies; Cluster Analysis; Cross Infection - epidemiology; Drug resistance; Drug Resistance, Microbial; Female; Health risk assessment; HIV; Hospital Bed Capacity, 500 and over; Hospital Design and Construction; Hospitals; Hospitals, Voluntary - statistics & numerical data; Human immunodeficiency virus; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Inpatients; Isoniazid - pharmacology; Length of Stay; Male; Medical research; Medical sciences; Multidrug resistant organisms; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - isolation & purification; New York - epidemiology; Streptomycin - pharmacology; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - transmission; New York; Human; Immunopathology; AIDS; Mycobacterial infection; Infection; Antibiotic; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; Viral disease; Mycobacteriaceae; Bacteriosis; Bacteria; Complication; Actinomycetes; Negative therapeutic reaction
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199206043262302

TUBERCULOSIS is an increasing cause of morbidity among persons with human immunodeficiency virus (HIV) infection in the United States. 1 As the number of patients hospitalized with HIV infection and tuberculosis increases, the risk of nosocomial transmission of tuberculosis may rise. Moreover, HIV-induced immunosuppression may amplify the spread of tuberculosis in hospitals because it greatly increases the risk of rapid progression to active, infectious tuberculosis. 2 In 1990 the first recognized clusters of primary multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome (AIDS) in the United States were reported to the Centers for Disease Control (CDC). 3 Twelve such clusters have . . .