Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi‐RLGS)

• Published in: Nucleic acids research Vol. 31; no. 15; pp. 4490 - 4496
• Main Authors: Matsuyama, Tomoki, Kimura, Makoto T., Koike, Kuniaki, Abe, Tomoko, Nakano, Takeshi, Asami, Tadao, Ebisuzaki, Toshikazu, Held, William A., Yoshida, Shigeo, Nagase, Hiroki
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2003; Oxford Publishing Limited (England)
• Subjects: Animals; Arabidopsis - genetics; Deoxyribonucleases, Type II Site-Specific - metabolism; DNA Methylation; Genome; Genome, Plant; Genomics - methods; Mice - genetics; Mice, Inbred C57BL; Organ Specificity; Restriction Mapping - methods; Software; User-Computer Interface

Understanding the role of ‘epigenetic’ changes such as DNA methylation and chromatin remodeling has now become critical in understanding many biological processes. In order to delineate the global methylation pattern in a given genomic DNA, computer software has been developed to create a virtual im...