Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

• Published in: Epidemiology and infection Vol. 138; no. 3; pp. 442 - 447
• Main Authors: MUKHOPADHYA, I., ANBU, D., ITURRIZA-GOMARA, M., GRAY, J. J., BROWN, D. W., KAVANAGH, O., ESTES, M. K., KANG, G.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2010
• Subjects: Adolescent; Adult; Age groups; Antibodies; Antigens, Viral - immunology; Biological and medical sciences; Capsid Proteins - immunology; Child; Child, Preschool; Childhood Infections; Children; Cloning; Diarrhea; Fundamental and applied biological sciences. Psychology; Gastroenteritis; Gastrointestinal infections; Humans; Immunoglobulin G - blood; Immunoglobulin G - immunology; India - epidemiology; Infant; infectious disease epidemiology; Microbiology; Miscellaneous; Proteins; Rotavirus; Rotavirus - classification; Rotavirus - immunology; Rotavirus Infections - epidemiology; Rotavirus Infections - immunology; Rural areas; Seroepidemiologic Studies; Serology; Standard deviation; Urban populations; Virology; Viruses; Young Adult; Asia; South Asia; India; United States > US; infectious disease epidemiology; rotavirus; Gastrointestinal infections; serology; Virus; Human; Rotavirus; Antibody; IgG; Epidemiology; Reoviridae
• ISSN: 0950-2688; 1469-4409; 1469-4409
• DOI: 10.1017/S0950268809990732

In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25·32% (95% CI 22·64–28·21). The lowest seroprevalence for group C was in children aged <10 years (16·79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.