Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats

• Published in: European journal of pharmacology Vol. 197; no. 2-3; p. 225
• Main Authors: Korte, S M, Van Duin, S, Bouws, G A, Koolhaas, J M, Bohus, B
• Format: Journal Article
• Language: English
• Published: Netherlands 17.05.1991
• Subjects: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Medulla - physiology; Animals; Corticosterone - blood; Epinephrine - blood; Hypothalamo-Hypophyseal System - physiology; Male; Norepinephrine - blood; Paraventricular Hypothalamic Nucleus - drug effects; Paraventricular Hypothalamic Nucleus - physiology; Pituitary-Adrenal System - physiology; Rats; Rats, Inbred Strains; Receptors, Serotonin - drug effects; Receptors, Serotonin - physiology; Serotonin - physiology; Sympathetic Nervous System - physiology; Tetrahydronaphthalenes - administration & dosage; Tetrahydronaphthalenes - pharmacology
• ISSN: 0014-2999
• DOI: 10.1016/0014-2999(91)90527-w

Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20 micrograms in 1 microliter during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.