MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth

• Published in: Cancer letters Vol. 333; no. 2; pp. 159 - 169
• Main Authors: Zhou, Bisheng, Ma, Ruihua, Si, Wenxia, Li, Sisi, Xu, Yan, Tu, Xin, Wang, Qing
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 10.06.2013; Elsevier Limited
• Subjects: 3' Untranslated Regions; Angiogenesis; Animals; Base Sequence; carcinogenesis; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cardiovascular disease; Cell division; Cloning; Colleges & universities; DNA Methylation; Down-Regulation; Enzymes; Epigenetics; Female; FGF2; Fibroblast Growth Factors - genetics; Gene expression; Gene Expression Regulation, Neoplastic; Hematology, Oncology and Palliative Medicine; Human Umbilical Vein Endothelial Cells - pathology; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Methylation; Mice; Mice, Inbred BALB C; microRNA; MicroRNAs; MicroRNAs - genetics; miR-503; Molecular Sequence Data; Mutagenesis; neoplasms; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Plasmids; Promoter Regions, Genetic; Tumors; Vascular Endothelial Growth Factor A - genetics; VEGFA; Xenograft Model Antitumor Assays; Angiogenesis; fibroblast growth factor-b; HCC; Methylation; vascular endothelial growth factor A; FGF2; HIF1α; miR-503; hypoxia inducible transcription factor 1α; VEGFA; hepatocellular carcinomas
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2013.01.028

Highlights ► MiR-503 simultaneously down-regulates expression of FGF2 and VEGFA and inhibits tumor angiogenesis and growth. ► MiR-503 expression is dramatically down-regulated in tumors by epigenetic hypermethylation of its promoter/regulatory region. ► This study identifies a novel miRNA-based alternative mechanism by which hypoxia increases expression of FGF2 and VEGFA.