Elective cryopreservation of all pronucleate embryos in women at risk of ovarian hyperstimulation syndrome: efficiency and safety

• Published in: Human reproduction (Oxford) Vol. 14; no. 6; pp. 1457 - 1460
• Main Authors: Ferraretti, A.P., Gianaroli, L., Magli, C., Fortini, D., Selman, H.A., Feliciani, E.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.1999
• Subjects: Adult; Biological and medical sciences; Chorionic Gonadotropin - therapeutic use; Cryopreservation; embryo; Embryo Transfer; Embryo, Mammalian; Female; Female genital diseases; Fertilization in Vitro; Follicle Stimulating Hormone - therapeutic use; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Non tumoral diseases; ovarian hyperstimulation; Ovarian Hyperstimulation Syndrome - prevention & control; Pregnancy; Pregnancy Outcome; Prospective Studies; Risk Factors; thawing; zygotes; thawing; embryo; zygotes; cryopreservation; ovarian hyperstimulation; Human; Embryo; Assisted procreation; Ovarian hyperstimulation syndrome; Thawing; Gonadotropin; Placental hormone; Female genital diseases; In vitro fertilization embryo transfer; Pregnancy; Prevention; Human chorionic gonadotrophin; Cryopreservation; Zygote; Complication; Woman
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/14.6.1457

In a prospective randomized study, we analysed 125 patients at risk of ovarian hyperstimulation syndrome (OHSS), selected in the period between January 1996 and July 1997. All the patients had blood oestradiol concentration ⩾1500 pg/ml on the day of human chorionic gonadotrophin (HCG) administration and ⩾15 oocytes were collected. The patients were matched in two groups: group A, control group (n = 67), had fresh embryo transfers; group B (n = 58) had cryopreservation of all obtained pronucleate embryos. Pregnancy, live birth rates and the incidence of OHSS were compared between the two groups. There were no significant differences in terms of pregnancies per patient (46.3 versus 48.3%) and live birth rates (38.8 versus 39.6%). No cases of OHSS occurred in group B, while four patients developed the syndrome in group A. The implantation rate was slightly but not significantly lower in group B (χ2 = 1.03). These results suggest that elective cryopreservation of all zygotes might prevent the risk of OHSS in patients undergoing IVF treatment. In contrast to what has been reported by other authors, our results show that the elective cryopreservation of zygotes does not affect pregnancy and live birth rates.