Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 3; pp. 755 - 759.e1
• Main Authors: Fischer, Jörg, MD, Hebsaker, Johanna, Caponetto, Patricia, MD, Platts-Mills, Thomas A.E., MD, PhD, Biedermann, Tilo, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2014; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Allergens - immunology; Allergies; Allergy and Immunology; alpha-Galactosidase - immunology; Anaphylaxis - etiology; Anaphylaxis - prevention & control; Animals; Beef; Biological and medical sciences; Cattle; Cross Reactions; Female; Food Hypersensitivity - complications; Food Hypersensitivity - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Hypersensitivity, Delayed - immunology; Immunization; Immunoglobulin E - immunology; Immunopathology; Kidney - immunology; Male; Mammals; Meat Products - adverse effects; Medical sciences; Middle Aged; Milk; Patients; Risk assessment; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Swine; Allergy; Immunopathology; Vertebrata; Anaphylaxis; Immunology; Mammalia; Urinary system; Sensitization; Galactose; Cofactor; Kidney; Pork
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2014.05.051

Importantly, IgE reactivity with [alpha]-Gal could be completely blocked by pre-incubating the serum with pork-kidney extracts, proving IgE cross-reactivity (Fig 2). [...]reactivity to pork meat using the ImmunoCAP assay was also completely blocked by pre-incubation with both pork-kidney extract and bovine thyroglobulin, demonstrating that in these patients, IgE recognition of the meat extract depends on IgE to [alpha]-Gal.