Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis
Importantly, IgE reactivity with [alpha]-Gal could be completely blocked by pre-incubating the serum with pork-kidney extracts, proving IgE cross-reactivity (Fig 2). [...]reactivity to pork meat using the ImmunoCAP assay was also completely blocked by pre-incubation with both pork-kidney extract and...
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Published in | Journal of allergy and clinical immunology Vol. 134; no. 3; pp. 755 - 759.e1 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.09.2014
Elsevier Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Importantly, IgE reactivity with [alpha]-Gal could be completely blocked by pre-incubating the serum with pork-kidney extracts, proving IgE cross-reactivity (Fig 2). [...]reactivity to pork meat using the ImmunoCAP assay was also completely blocked by pre-incubation with both pork-kidney extract and bovine thyroglobulin, demonstrating that in these patients, IgE recognition of the meat extract depends on IgE to [alpha]-Gal. |
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ISSN: | 0091-6749 1097-6825 |
DOI: | 10.1016/j.jaci.2014.05.051 |