Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

• Published in: The New England journal of medicine Vol. 384; no. 23; pp. 2259 - 2261
• Main Authors: Doria-Rose, Nicole, Suthar, Mehul S, Makowski, Mat, O’Connell, Sarah, McDermott, Adrian B, Flach, Britta, Ledgerwood, Julie E, Mascola, John R, Graham, Barney S, Lin, Bob C, O’Dell, Sijy, Schmidt, Stephen D, Widge, Alicia T, Edara, Venkata-Viswanadh, Anderson, Evan J, Lai, Lilin, Floyd, Katharine, Rouphael, Nadine G, Zarnitsyna, Veronika, Roberts, Paul C, Makhene, Mamodikoe, Buchanan, Wendy, Luke, Catherine J, Beigel, John H, Jackson, Lisa A, Neuzil, Kathleen M, Bennett, Hamilton, Leav, Brett, Albert, Jim, Kunwar, Pratap
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 10.06.2021
• Subjects: 2019-nCoV Vaccine mRNA-1273; Adult; Age; Aged; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 vaccines; COVID-19 Vaccines - immunology; Half-Life; Humans; Medical research; Middle Aged; mRNA; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Vaccination; Vaccines; North Carolina; United States > US
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMc2103916

A total of 33 participants who received both doses of the Moderna mRNA-1273 vaccine against SARS-CoV-2 had blood drawn over a period of 6 months after vaccination. SARS-CoV-2 neutralizing activity was maintained in all the patients through the entire period of follow-up. A half-life of 202 days was determined for the live-virus neutralization activity.