Liver Safety of Statins in Prediabetes or T2DM and Nonalcoholic Steatohepatitis: Post Hoc Analysis of a Randomized Trial

• Published in: The journal of clinical endocrinology and metabolism Vol. 102; no. 8; pp. 2950 - 2961
• Main Authors: Bril, Fernando, Portillo Sanchez, Paola, Lomonaco, Romina, Orsak, Beverly, Hecht, Joan, Tio, Fermin, Cusi, Kenneth
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.08.2017; Copyright Oxford University Press; Oxford University Press
• Subjects: Alanine; Alanine transaminase; Alanine Transaminase - metabolism; Aspartate Aminotransferases - metabolism; Biopsy; Cardiovascular Diseases; Clinical s; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Dyslipidemias - complications; Dyslipidemias - drug therapy; Fatty liver; Female; Glucose Clamp Technique; Glucose tolerance; Health risk assessment; Health risks; Hepatotoxicity; Histology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypoglycemic Agents - therapeutic use; Insulin; Insulin resistance; Liver; Liver - metabolism; Liver - pathology; Liver diseases; Magnetic Resonance Spectroscopy; Male; Middle Aged; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Pioglitazone; Population studies; Prediabetic State - complications; Prediabetic State - drug therapy; Risk assessment; Safety; Spectroscopy; Statins; Thiazolidinediones - therapeutic use
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2017-00867

Abstract Context Patients with nonalcoholic fatty liver disease have a high cardiovascular risk, but statins are rarely prescribed because of fear of hepatotoxicity. Objective To prospectively assess the long-term safety of statins in patients with prediabetes/type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH). Design Post hoc analysis of statin use during a randomized, controlled trial assessing pioglitazone vs placebo for NASH. Patients A total of 101 patients (86 receiving statins) with biopsy-proven NASH and prediabetes/T2DM were followed for up to 36 months. Interventions Oral glucose tolerance test and percutaneous liver biopsy (baseline, month 18, and month 36); liver magnetic resonance spectroscopy and euglycemic insulin clamp (baseline and month 18). Main Outcome Measures Histologic and biochemical safety of statin use among patients with NASH. Results Only 37% of patients were receiving statins at enrollment despite their high cardiovascular risk. Statin nonusers had higher plasma alanine aminotransferase levels but similar histologic severity of liver disease at baseline. In both statin users and nonusers, the same number of patients (n = 4) had a twofold or greater increase in plasma aminotransferases during follow-up. One statin nonuser was discontinued from the study because of this elevation. Values returned to normal without any active measure in all other cases. No changes on liver histology or hepatic insulin resistance were observed in patients with NASH newly started on a statin and receiving placebo during the main study. Conclusions Statin therapy is safe in patients with prediabetes/T2DM and NASH. Given their high cardiovascular risk, statin therapy should be encouraged in this population. This study prospectively assessed the histologic safety of statins in patients with prediabetes or T2DM and NASH and found that statins can safely be used in this high-risk population.