Resveratrol in the treatment of pancreatic cancer

• Published in: Annals of the New York Academy of Sciences Vol. 1348; no. 1; pp. 10 - 19
• Main Authors: Xu, Qinhong, Zong, Liang, Chen, Xin, Jiang, Zhengdong, Nan, Ligang, Li, Jiahui, Duan, Wanxing, Lei, Jianjun, Zhang, Lun, Ma, Jiguang, Li, Xuqi, Wang, Zheng, Wu, Zheng, Ma, Qingyong, Ma, Zhenhua
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; apoptosis; Apoptosis - drug effects; Cell cycle; cell cycle arrest; Cell Cycle Checkpoints; Cell Proliferation - drug effects; chemosensitization; epithelial-mesenchymal transition; Humans; Medical prognosis; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; proliferation; resveratrol; Stilbenes - pharmacology; Stilbenes - therapeutic use; apoptosis; chemosensitization; epithelial-mesenchymal transition; proliferation; cell cycle arrest; resveratrol
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1111/nyas.12837

Pancreatic cancer (PCa), which is now the fourth most frequent cause of cancer‐related death, has a median survival of less than 6 months and a 5‐year survival rate of <6%. The hallmarks of this cancer include poor outcome, short survival duration, and resistance to therapy. The poor prognosis of PCa is related to its local recurrence, lymph node and liver metastases, and peritoneal dissemination. Recent studies have indicated that resveratrol has cancer‐chemopreventive and anticancer activities. In this short review we summarize the chemopreventive and treatment effects of resveratrol in PCa, as follows: resveratrol inhibits the proliferation of pancreatic cancer cells; induces apoptosis and cell cycle arrest; inhibits metastasis and invasion of PCa cells; inhibits the proliferation and viability of PCa stem cells; enhances the chemoradiosensitization of PCa cells; and can affect diabetes mellitus in addition to PCa. On the basis of these data, resveratrol may be considered a potential anticancer agent for the treatment of PCa.