Medicinal Perspective of 2,4‐Thiazolidinediones Derivatives: An Insight into Recent Advancements

• Published in: ChemistryOpen (Weinheim) Vol. 13; no. 11; pp. e202400147 - n/a
• Main Authors: Gupta, Sneha, Jha, Sumeet, Rani, Supriya, Arora, Pinky, Kumar, Shubham
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.11.2024; John Wiley and Sons Inc; Wiley-VCH
• Subjects: 2,4-Thiazolidinedione; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anticancer; Anticonvulsants; Anticonvulsants - chemistry; Anticonvulsants - pharmacology; Anticonvulsants - therapeutic use; Antidiabetics; Antimicrobial; Antimicrobial agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants - chemistry; Antioxidants - pharmacology; Apoptosis; Biological activity; Biological properties; Cancer; Cell cycle; Cell growth; Chemical synthesis; Corrosion prevention; Cytokines; Cytotoxicity; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - drug therapy; Enzymes; Fractures; Gene expression; Glucose; Gram-negative bacteria; Heart failure; Heterocyclic compounds; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - metabolism; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; In vivo methods and tests; Insulin resistance; Mechanism of Action; Metabolism; Pharmaceuticals; Pharmacokinetics; Pharmacology; Recent Advances; Review; RNA polymerase; Side effects; Structure-Activity Relationship; Thiazolidinediones - chemistry; Thiazolidinediones - pharmacology; Thiazolidinediones - therapeutic use; United States > US; Antimicrobial; Recent Advances; Mechanism of Action; Review; Anticancer; 2,4-Thiazolidinedione

2,4‐Thiazolidinedione derivatives represent nitrogen‐containing heterocyclic compounds utilized in type 2 diabetes mellitus management. Recent advances in medicinal chemistry have unveiled diverse therapeutic potentials and structural modifications of these derivatives. This review delves into novel...