Mycobacterium avium ssp. hominissuis biofilm is composed of distinct phenotypes and influenced by the presence of antimicrobials

• Published in: Clinical microbiology and infection Vol. 17; no. 5; pp. 697 - 703
• Main Authors: McNabe, M., Tennant, R., Danelishvili, L., Young, L., Bermudez, L.E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01.05.2011; Blackwell Publishing Ltd; Wiley-Blackwell; Elsevier Limited
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; biofilm; Biofilms - drug effects; Biological and medical sciences; Bronchiectasis - drug therapy; Bronchiectasis - microbiology; DNA-Binding Proteins; Drug Resistance, Bacterial; gene expression; Infectious diseases; Lung - microbiology; M. avium; Medical sciences; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mycobacterium avium - drug effects; Mycobacterium avium - genetics; Mycobacterium avium - physiology; Pharmacology. Drug treatments; Phenotype; Polymerase Chain Reaction; M. avium; Antibiotics; gene expression; biofilm; avium; Mycobacterium avium; Gene expression; M; Antimicrobial agent; Infection; Antibiotic; Phenotype; Mycobacteriales; Mycobacteriaceae; Biofilm; Bacteria; Actinomycetes; Antibacterial agent

Mycobacterium avium ssp. hominissuis, hereafter referred to as M. avium, forms biofilm, a property that, in mice, is associated with lung infection via aerosol. As M. avium might co‐inhabit the respiratory tract with other pathogens, treatment of the co‐pathogen‐associated infections, such as in bro...