Role of cellulose in wood dust-induced fibrosing alveo-bronchiolitis in rat

Our experiments suggest that in the development of plant dust-induced fibrosing alveobronchiolitis--Scadding's fibrosing alveolitis--the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomat...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 15; no. 1; p. 45
Main Authors Tátrai, E, Adamis, Z, Böhm, U, Merétey, K, Ungváry, G
Format Journal Article
LanguageEnglish
Published England 01.01.1995
Subjects
Animals
Cellulose - toxicity
Disease Models, Animal
Dose-Response Relationship, Drug
Dust - adverse effects
Giant Cells - cytology
Granulocytes - cytology
Granulocytes - drug effects
Humans
Hydrogen Peroxide - metabolism
In Vitro Techniques
Lung - drug effects
Lung - pathology
Lymph Nodes - drug effects
Lymph Nodes - pathology
Male
Occupational Exposure
Oxygen - metabolism
Particle Size
Pulmonary Fibrosis - chemically induced
Rats
Rats, Sprague-Dawley
Trachea - drug effects
Trachea - metabolism
Wood
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Summary:Our experiments suggest that in the development of plant dust-induced fibrosing alveobronchiolitis--Scadding's fibrosing alveolitis--the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomatous inflammation and fibrosis, whereas the fibre-free extract of wood dust did not cause pathological changes in the lungs. The induction of H2O2 and superoxide anion production, shown in vitro in leucocytes, probably has an important role in the development of fibrosis.
ISSN:0260-437X
DOI:10.1002/jat.2550150110