Biological (Homo-, Heterologous) Aortic Valve Replacement

• Published in: JAPANESE CIRCULATION JOURNAL Vol. 33; no. 10; pp. 1065 - 1078
• Main Author: SENOO, YOSHIMASA
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 01.01.1969
• Subjects: Adolescent; Adult; Animals; Aortic Valve - transplantation; Blood Pressure; Dogs; Elasticity; Female; Heart Valve Diseases - surgery; Histocompatibility; Humans; Male; Methods; Tissue Preservation; Transplantation Immunology; Transplantation, Heterologous; Transplantation, Homologous
• ISSN: 0047-1828; 1347-4839
• DOI: 10.1253/jcj.33.1065

Fresh heterologous aortic valve has a stronger antigenicity than fresh homologous valve, but preserved heterologous valve shows antigenicity only in about the same degree as fresh homologous valve. The tensile strength of such a preserved valve differs not much from that of fresh valve. On the basis of these findings, the replacement surgery was performed on 10 patients with aortic valvular disease using preserved homograft or preserved heterograft. For operative procedures continuous single layer suture coupled with mattress suture of the lower end of commissure were employed, but no leakage was observed due to this method. Excepting the two cases which required the change to prosthesis immediately after the operation, two cases of the 8 showed postoperative systolic gradient across the aortic valve of 15-20 mmHg. Three cases died due to the cerebral damage, postoperative respiratory disturbances and acute bacterial endocarditis resulting from the heart-lung bypass, and one case required reoperation due to aortic incompetence by the rupture of cusp. Those given homograft amount to 4 cases, those receiving heterograft 6 cases; and the formalin preserved valves were given to 5 cases and the freeze-dried valves to 5 cases, but there could be observed no prominent difference in these cases. While the number of cases handled is small and the results are also not quite so satisfactory, it has been demonstrated that biologic valves including preserved heterologous valves are excellent for the substitute valve. Therefore, the results are present as a preliminary report of the study in this line.