Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

• Published in: Clinical & experimental metastasis Vol. 28; no. 5; pp. 493 - 503
• Main Authors: PosthumaDeBoer, J., Witlox, M. A., Kaspers, G. J. L., van Royen, B. J.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2011; Springer Nature B.V
• Subjects: Antineoplastic Combined Chemotherapy Protocols - pharmacology; Biomedical and Life Sciences; Biomedicine; Bone Neoplasms - drug therapy; Bone Neoplasms - pathology; Cancer Research; Hematology; Humans; Molecular Targeted Therapy; Neoplasm Metastasis - drug therapy; Neoplasm Metastasis - pathology; Oncology; Osteosarcoma - drug therapy; Osteosarcoma - pathology; Review; Surgical Oncology; Therapy; Metastasis; Drug resistance; Osteosarcoma
• ISSN: 0262-0898; 1573-7276
• DOI: 10.1007/s10585-011-9384-x

Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.