Visual gamma oscillations predict sensory sensitivity in females as they do in males

• Published in: Scientific reports Vol. 11; no. 1; p. 12013
• Main Authors: Manyukhina, Viktoriya O, Rostovtseva, Ekaterina N, Prokofyev, Andrey O, Obukhova, Tatiana S, Schneiderman, Justin F, Stroganova, Tatiana A, Orekhova, Elena V
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 08.06.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adolescent; Adult; Autism; Autism Spectrum Disorder - physiopathology; band oscillations; Biomarkers; Brain Mapping; Brain research; children; contrast gain-control; cortex; eeg; Excitability; Female; Females; gaba; Gamma Rhythm - physiology; Humans; Hypersensitivity; Information processing; inhibition; Life Style; Magnetic Resonance Imaging - methods; Magnetoencephalography; Magnetoencephalography - methods; Male; Males; meg; Menstruation; Motion Perception - physiology; Neural networks; Neurosciences; Neurovetenskaper; Oscillations; Oscillometry - methods; peak frequency; Photic Stimulation - methods; Science & Technology - Other Topics; Sensory stimuli; Sex Factors; Somatosensory cortex; synchronization; Velocity; Visual cortex; Visual Cortex - physiopathology; Visual Perception - physiology; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-91381-2

Gamma oscillations are driven by local cortical excitatory (E)-inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.