Posterior reversible encephalopathy syndrome as a multiple sclerosis relapse mimic during interferon therapy

Posterior reversible encephalopathy syndrome is a rare syndrome involving the subcortical cerebral white matter. We describe the case of a 63-year-old male patient with relapsing remitting multiple sclerosis under interferon beta therapy and acute onset of atypical unilateral posterior reversible en...

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Bibliographic Details
Published inClinical neurology and neurosurgery Vol. 249; p. 108666
Main Authors Dias da Costa, Mariana, Leal Rato, Miguel, Ferreira, João, de Sá, João, Santos, Mónica
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2025
Elsevier
Elsevier Limited
Subjects
Blood pressure
Blood-brain barrier
Brain - pathology
Diagnosis, Differential
Edema
Editing
Encephalopathy
Humans
Hypertension
Interferon
Interferon-beta - adverse effects
Interferon-beta - therapeutic use
Intracranial stenosis
Magnetic Resonance Imaging
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Multiple Sclerosis, Relapsing-Remitting - drug therapy
Neurology
Neurosurgery
Patients
Posterior Leukoencephalopathy Syndrome - chemically induced
Posterior Leukoencephalopathy Syndrome - diagnosis
Posterior Leukoencephalopathy Syndrome - pathology
PRES
Recurrence
Spinal cord
Steroids
Substantia alba
Supervision
Multiple sclerosis
Interferon
PRES
Intracranial stenosis
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Summary:Posterior reversible encephalopathy syndrome is a rare syndrome involving the subcortical cerebral white matter. We describe the case of a 63-year-old male patient with relapsing remitting multiple sclerosis under interferon beta therapy and acute onset of atypical unilateral posterior reversible encephalopathy syndrome mimicking a relapse. This case highlights the importance of clinical suspicion for multiple sclerosis mimics, namely in older patients, which may need disease modifying treatment suspension and directed treatment in order to achieve better clinical prognosis. •Multiple sclerosis mimics include other disorders that affect the white matter, such as PRES.•Diagnosing MS mimics is of utmost importance to guarantee adequate treatment.•PRES has been previously associated with disease modifying treatments in MS, such as interferon beta.
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ISSN:0303-8467
1872-6968
1872-6968
DOI:10.1016/j.clineuro.2024.108666