Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy

Highlights • Rhynchophylline (RIN) reduced behavioral and electrographic seizure severity. • RIN protected mEC layer III neurons from pilocarpine-induced neuronal death. • RIN terminated pilocarpine-induced hyperexcitability of EC layer II neurons. • RIN rectified pilocarpine-induced alternation of...

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Bibliographic Details
Published inNeuroscience Vol. 337; pp. 355 - 369
Main Authors Shao, Hui, Yang, Yang, Zhu, Guang-xi, Mi, Ze, Qi, Ai-ping, Ji, Wei-gang, Zhu, Zhi-ru
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 19.11.2016
Subjects
Animals
Anticonvulsants - pharmacology
Disease Models, Animal
entorhinal cortex
Entorhinal Cortex - drug effects
Epilepsy, Temporal Lobe - drug therapy
Epilepsy, Temporal Lobe - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
Indole Alkaloids - pharmacology
Neurology
Neurons - metabolism
NMDA receptor current
persistent sodium current
Pilocarpine - pharmacology
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - drug effects
Receptors, N-Methyl-D-Aspartate - metabolism
Rhynchophylline
Sodium - metabolism
Status Epilepticus - chemically induced
temporal lobe epilepsy
interspike interval
DMSO
dimethylsulfoxide
diazepam
entorhinal cortex
mEC
phosphate-buffered saline
TLE
I NaP
SE
analysis of variance
ANOVA
FFT
Rhynchophylline
EC
ISI
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
PBS
temporal lobe epilepsy
EEG
Fast Fourier Transform
ethylene glycol-bis(β-aminoethyl ether)- N, N, N′, N′-tetraacetic acid
electroencephalogram
EGTA
status epilepticus
NMDA receptor current
HEPES
RIN
DZP
medial entorhinal cortex
persistent sodium current
s.c
i.p
INaP
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Summary:Highlights • Rhynchophylline (RIN) reduced behavioral and electrographic seizure severity. • RIN protected mEC layer III neurons from pilocarpine-induced neuronal death. • RIN terminated pilocarpine-induced hyperexcitability of EC layer II neurons. • RIN rectified pilocarpine-induced alternation of INaP and Nav1.6 protein expression. • RIN rectified pilocarpine-induced alternation of NMDA currents and NR2B expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.09.029