Autism spectrum disorders and intestinal microbiota
Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children wit...
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| Published in | Gut microbes Vol. 6; no. 3; pp. 207 - 213 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Taylor & Francis
01.01.2015
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| Subjects | |
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| Abstract | Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children with pervasive developmental disorder-not otherwise specified (PDD-NOS) or autism (AD) compared with healthy children (HC). Children with PDD-NOS or AD have altered fecal microbiota and metabolomes (including neurotransmitter molecules). We hypothesize that the degree of microbial alteration correlates with the severity of the disease since fecal microbiota and metabolomes alterations were higher in children with PDD-NOS and, especially, AD compared to HC. Our study indicates that the levels of free amino acids (FAA) and volatile organic compounds (VOC) differ in AD subjects compared to children with PDD-NOS, who are more similar to HC. Finally, we propose a new perspective on the implications for the interaction between intestinal microbiota and AD. |
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| AbstractList | Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children with pervasive developmental disorder-not otherwise specified (PDD-NOS) or autism (AD) compared with healthy children (HC). Children with PDD-NOS or AD have altered fecal microbiota and metabolomes (including neurotransmitter molecules). We hypothesize that the degree of microbial alteration correlates with the severity of the disease since fecal microbiota and metabolomes alterations were higher in children with PDD-NOS and, especially, AD compared to HC. Our study indicates that the levels of free amino acids (FAA) and volatile organic compounds (VOC) differ in AD subjects compared to children with PDD-NOS, who are more similar to HC. Finally, we propose a new perspective on the implications for the interaction between intestinal microbiota and AD. Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children with pervasive developmental disorder–not otherwise specified (PDD-NOS) or autism (AD) compared with healthy children (HC). Children with PDD-NOS or AD have altered fecal microbiota and metabolomes (including neurotransmitter molecules). We hypothesize that the degree of microbial alteration correlates with the severity of the disease since fecal microbiota and metabolomes alterations were higher in children with PDD-NOS and, especially, AD compared to HC. Our study indicates that the levels of free amino acids (FAA) and volatile organic compounds (VOC) differ in AD subjects compared to children with PDD-NOS, who are more similar to HC. Finally, we propose a new perspective on the implications for the interaction between intestinal microbiota and AD. |
| Author | De Angelis, Maria De Giacomo, Andrea Piccolo, Maria Gobbetti, Marco Francavilla, Ruggiero |
| Author_xml | – sequence: 1 givenname: Maria surname: De Angelis fullname: De Angelis, Maria email: maria.deangelis@uniba.it organization: Department of Soil; Plant and Food Sciences; University of Bari Aldo Moro – sequence: 2 givenname: Ruggiero surname: Francavilla fullname: Francavilla, Ruggiero organization: Department of Interdisciplinary Medicine; University of Bari Aldo Moro – sequence: 3 givenname: Maria surname: Piccolo fullname: Piccolo, Maria organization: Department of Soil; Plant and Food Sciences; University of Bari Aldo Moro – sequence: 4 givenname: Andrea surname: De Giacomo fullname: De Giacomo, Andrea organization: Child Neurological and Psychiatric Unit; Department of Neurological and Psychiatric Sciences; University of Bari Aldo Moro – sequence: 5 givenname: Marco surname: Gobbetti fullname: Gobbetti, Marco organization: Department of Soil; Plant and Food Sciences; University of Bari Aldo Moro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25835343$$D View this record in MEDLINE/PubMed |
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| Snippet | Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via... Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via... |
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| SubjectTerms | Addendum - Invited Amino Acids - analysis ASD Child Development Disorders, Pervasive - epidemiology Child Development Disorders, Pervasive - microbiology dysbiosis Dysbiosis - complications Feces - chemistry Gastrointestinal Microbiome Humans intestinal microbiota metabolome Microbiota perspective Volatile Organic Compounds - analysis |
| Title | Autism spectrum disorders and intestinal microbiota |
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