Autism spectrum disorders and intestinal microbiota

Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children wit...

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Published inGut microbes Vol. 6; no. 3; pp. 207 - 213
Main Authors De Angelis, Maria, Francavilla, Ruggiero, Piccolo, Maria, De Giacomo, Andrea, Gobbetti, Marco
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2015
Subjects
Addendum - Invited
Amino Acids - analysis
ASD
Child Development Disorders, Pervasive - epidemiology
Child Development Disorders, Pervasive - microbiology
dysbiosis
Dysbiosis - complications
Feces - chemistry
Gastrointestinal Microbiome
Humans
intestinal microbiota
metabolome
Microbiota
perspective
Volatile Organic Compounds - analysis
intestinal microbiota
perspective
ASD
metabolome
dysbiosis
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Summary:Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children with pervasive developmental disorder-not otherwise specified (PDD-NOS) or autism (AD) compared with healthy children (HC). Children with PDD-NOS or AD have altered fecal microbiota and metabolomes (including neurotransmitter molecules). We hypothesize that the degree of microbial alteration correlates with the severity of the disease since fecal microbiota and metabolomes alterations were higher in children with PDD-NOS and, especially, AD compared to HC. Our study indicates that the levels of free amino acids (FAA) and volatile organic compounds (VOC) differ in AD subjects compared to children with PDD-NOS, who are more similar to HC. Finally, we propose a new perspective on the implications for the interaction between intestinal microbiota and AD.
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Addendum to: De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, Cristofori F, Guerzoni ME, Gobbetti M, Francavilla R. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. Nine; 8(10):e76993.
ISSN:1949-0976
1949-0984
DOI:10.1080/19490976.2015.1035855