Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life

• Published in: Brain research bulletin Vol. 120; pp. 25 - 33
• Main Authors: Yang, Junhua, Qi, Fangfang, Gu, Huaiyu, Zou, Juntao, Yang, Yang, Yuan, Qunfang, Yao, Zhibin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2016
• Subjects: Animals; Animals, Newborn; Anxiety Disorders - immunology; Anxiety Disorders - prevention & control; Basic Helix-Loop-Helix Transcription Factors - blood; BCG Vaccine; Cytokine; Female; Hippocampus; Hippocampus - cytology; Hippocampus - immunology; Interferon-gamma - blood; Interleukin-4; Male; Maze Learning; Microglia; Microglia - cytology; Microglia - immunology; Motor Activity - immunology; Neurogenesis - immunology; Neurology; Neurotrophin; Spatial Memory; Th bias; Vaccine; interleukin-4; Neurotrophin; doublecortin; DG; EPM; insulin-like growth factor-1; phosphate-buffered saline; interleukin-6; 5-bromo-2-deoxy uridine; neuronal nuclei; IFN-γ; Th; brain-derived neurotrophic factor; T helper; PBS; postnatal day 0; BCG; Cytokine; IL-4; IGF-1; IL-1β; IL-6; central nervous system; Microglia; Th bias; dentate gyrus; NeuN; transforming growth factor-β; Dcx; RM-ANOVA; open field test; glial fibrillary acidic protein; Hippocampus; interferon-γ; Morris water maze; CNS; elevated plus maze; interleukin-1β; tumor necrosis factor-α and w, weeks; TGF-β; OFT; Iba-1; Sun Yat-Sen University; P0; MWM; BDNF; ionized calcium-binding adaptor molecule 1; Vaccine; GFAP; SYSU; Bacillus Calmette–Guérin; TNF-α; repeated measures analysis of variance; BrdU
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2015.10.012

Highlights • Neonatal BCG vaccination improved mice neurogenesis and behavior at 4 weeks old. • Neonatal BCG vaccination induced M2 microglial activation at 2 weeks. • BCG induced a neurotrophic hippocampal neuroimmune molecular profile. • Serum Th1 bias correlates positively to hippocampal neurotrophins levels. • Serum Th1 bias correlates positively to hippocampal neurogenesis levels.