Circadian rhythm of histamine release from the hypothalamus of freely moving rats

Using an in vivo microdialysis technique coupled with HPLC-fluorometry, the release of neuronal histamine from the anterior hypothalamic area was monitored continuously in conscious, freely moving rats under a 12:12 h light:dark cycle. Spontaneous locomotor activity of the rats was measured simultan...

Full description

Saved in:
Bibliographic Details
Published inPhysiology & behavior Vol. 51; no. 2; p. 391
Main Authors Mochizuki, T, Yamatodani, A, Okakura, K, Horii, A, Inagaki, N, Wada, H
Format Journal Article
LanguageEnglish
Published United States 01.02.1992
Subjects
Animals
Circadian Rhythm - physiology
Histamine - metabolism
Hypothalamus, Anterior - physiology
Male
Motor Activity - physiology
Rats
Rats, Inbred Strains
Synaptic Transmission - physiology
Online AccessGet more information

Cover

More Information
Summary:Using an in vivo microdialysis technique coupled with HPLC-fluorometry, the release of neuronal histamine from the anterior hypothalamic area was monitored continuously in conscious, freely moving rats under a 12:12 h light:dark cycle. Spontaneous locomotor activity of the rats was measured simultaneously using a locomotor activity counter. Histamine release gradually increased in the second half of the light period (1400-2000) and the average histamine release during the dark period (2000-0800, 0.20 +/- 0.02 pmol/30 min) was significantly higher than that during the light period (0.12 +/- 0.01 pmol/30 min). This clear circadian change in the release suggests that the central histaminergic system is related to the circadian rhythm of rats.
ISSN:0031-9384
DOI:10.1016/0031-9384(92)90157-W