Periostin upregulates the effector functions of eosinophils

Eosinophils were obtained from healthy volunteers or allergic subjects with allergic rhinitis, and their adhesion to periostin or vascular cell adhesion molecule (VCAM)-1 was measured using residual eosinophil peroxidase assays (see this article's Methods section in the Online Repository at www...

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Published inJournal of allergy and clinical immunology Vol. 138; no. 5; pp. 1449 - 1452.e5
Main Authors Noguchi, Toru, Nakagome, Kazuyuki, Kobayashi, Takehito, Uchida, Yoshitaka, Soma, Tomoyuki, Nakamoto, Hidetomo, Nagata, Makoto
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Elsevier Limited
Subjects
Allergy and Immunology
Asthma
Cell adhesion & migration
Chemokines
Cytokines
Fibroblasts
Proteins
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Summary:Eosinophils were obtained from healthy volunteers or allergic subjects with allergic rhinitis, and their adhesion to periostin or vascular cell adhesion molecule (VCAM)-1 was measured using residual eosinophil peroxidase assays (see this article's Methods section in the Online Repository at www.jacionline.org). [...]the viability after 48-hour culture was much decreased to about 40% to 60% (Fig E1; 46.6% [without stimulation], 66.8% [+IL-5], or 47.0% [+periostin]). [...]in this study, we incubated eosinophils for 24 hours for cytokine measurement.
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ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2016.05.020