Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats

• Published in: Neuroscience Vol. 300; pp. 593 - 608
• Main Authors: Kovács, Z, Kékesi, K.A, Dobolyi, Á, Lakatos, R, Juhász, G
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 06.08.2015
• Subjects: absence epilepsy; Animals; Anticonvulsants - pharmacology; Brain - drug effects; Brain - physiopathology; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocorticography; Epilepsy, Absence - drug therapy; Epilepsy, Absence - physiopathology; guanosine; Guanosine - pharmacology; inosine; Inosine - pharmacology; Male; Neurology; Rats, Wistar; Receptors, GABA-A - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Receptors, Purinergic P1 - metabolism; uridine; Uridine - pharmacology; WAG/Rij rats; slow wave sleep; GTP; inosine; N-methyl- d-aspartate; Urd; quinolinic acid; WAG/Rij; WAG/Rij rats; Ino; Ado; rapid eye movement; QA; uridine; UTP; guanosine diphosphate; MK-801; GDP; A 2A receptors; analysis of variance; electroencephalographic recording; ANOVA; PTZ; pentylenetetrazole; spike-wave discharge; NMDA; Wistar Albino Glaxo/Rijswijk; A 2A type of Ado receptors; Non-Ado; Guo; SWD; absence epilepsy; intraperitoneal; (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate; guanosine triphosphate; i.p; GMP; S.E.M; SWS; adenosine; non-adenosine; guanosine; GABA A receptors; REM; standard error of the mean; uridine triphosphate; GABA A type of gamma-aminobutyric acid receptors; EEG recording; guanosine monophosphate; A2A receptors; GABAA receptors
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.05.054

Highlights • Guanosine (Guo) and uridine (Urd) decreased the number of spike-wave discharges (SWDs). • Adenosine receptors, GABAA receptors and glutamate may be involved in Guo and Urd-evoked effects. • The effects of Guo and Urd may also be exerted through their own putative receptors. • Inosine increased SWD number dose-dependently mainly via GABAA receptors. • Guo, Urd and their analogs may be effective drugs for treatment of absence epilepsy.