Nicotinic acetylcholine binding sites in Alzheimer's disease
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissue...
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| Published in | Brain research Vol. 371; no. 1; p. 146 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
16.04.1986
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| Subjects | |
| Online Access | Get more information |
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| Abstract | In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD. |
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| AbstractList | In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD. |
| Author | Whitehouse, P J Antuono, P G Lowenstein, P R Price, D L Martino, A M Coyle, J T Kellar, K J |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3708340$$D View this record in MEDLINE/PubMed |
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| PublicationTitle | Brain research |
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| PublicationYear | 1986 |
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| Snippet | In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is... |
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| SubjectTerms | Acetylcholine - metabolism Aged Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - metabolism Cerebral Cortex - analysis Cerebral Cortex - enzymology Cerebral Cortex - metabolism Choline O-Acetyltransferase - metabolism Humans Nicotine - metabolism Receptors, Nicotinic - analysis |
| Title | Nicotinic acetylcholine binding sites in Alzheimer's disease |
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