Nicotinic acetylcholine binding sites in Alzheimer's disease

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissue...

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Bibliographic Details
Published inBrain research Vol. 371; no. 1; p. 146
Main Authors Whitehouse, P J, Martino, A M, Antuono, P G, Lowenstein, P R, Coyle, J T, Price, D L, Kellar, K J
Format Journal Article
LanguageEnglish
Published Netherlands 16.04.1986
Subjects
Acetylcholine - metabolism
Aged
Alzheimer Disease - drug therapy
Alzheimer Disease - enzymology
Alzheimer Disease - metabolism
Cerebral Cortex - analysis
Cerebral Cortex - enzymology
Cerebral Cortex - metabolism
Choline O-Acetyltransferase - metabolism
Humans
Nicotine - metabolism
Receptors, Nicotinic - analysis
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Summary:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
ISSN:0006-8993
DOI:10.1016/0006-8993(86)90819-x