Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study

Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired vo...

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Bibliographic Details
Published inBrain sciences Vol. 10; no. 9; p. 627
Main Authors Lee, Kyoung Bo, Lim, Seong Hoon, Park, Geun-Young, Im, Sun
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2020
MDPI
Subjects
Brain
Brain diseases
brain mapping
Complications and side effects
Cough
Frontal lobe
Lesions
Magnetic resonance imaging
Mapping
mechanisms
Medical imaging
Medical records
Neuroimaging
Observational studies
Patients
Pneumonia
Risk factors
Software
Stroke
Stroke (Disease)
Temporal gyrus
South Korea
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Summary:Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired voluntary cough. Here, we studied the effects of stroke lesions on voluntary cough using voxel-based lesion-symptom mapping (VLSM). In this retrospective cross-sectional study, the peak cough flow was measured in patients who complained of weak cough (n = 39) after supratentorial lesions. Brain lesions were visualized via magnetic resonance imaging (MRI) at the onset of stroke. These lesions were studied using VLSM. The VLSM method with non-parametric mapping revealed that lesions in the sub-gyral frontal lobe and superior longitudinal and posterior corona radiata were associated with a weak cough flow. In addition, lesions in the inferior parietal and temporal lobes and both the superior and mid-temporal gyrus were associated with a weak peak cough flow during voluntary coughing. This study identified several brain lesions underlying impaired voluntary cough. The results might be useful in predicting those at risk of poor cough function and may improve the prognosis of patients at increased risk of respiratory complications after a stroke.
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ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci10090627