Edible bird's nest extract inhibits influenza virus infection

• Published in: Antiviral research Vol. 70; no. 3; pp. 140 - 146
• Main Authors: Guo, Chao-Tan, Takahashi, Tadanobu, Bukawa, Wakoto, Takahashi, Noriko, Yagi, Hirokazu, Kato, Koichi, Hidari, Kazuya I.-P. Jwa, Miyamoto, Daisei, Suzuki, Takashi, Suzuki, Yasuo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2006; Elsevier
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Aves; Biological and medical sciences; Bird nest; Birds; Cell Line; Hemagglutination Inhibition Tests; Human viral diseases; Humans; Infectious diseases; Influenza; Influenza A virus - classification; Influenza A virus - drug effects; Influenza A virus - metabolism; Influenza A virus - pathogenicity; Influenza virus; Influenza, Human - virology; Medical sciences; N-Acetylneuraminic Acid - chemistry; Neuraminidase - antagonists & inhibitors; Pharmacology. Drug treatments; Saliva - chemistry; Saliva - metabolism; Sialic acid; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Sialic acid; Influenza; Bird nest; Orthomyxoviridae; Extract; Foodstuff; Influenzavirus; Infection; Virus; Vertebrata; Viral disease; Antiviral; Aves; Nest
• ISSN: 0166-3542; 1872-9096
• DOI: 10.1016/j.antiviral.2006.02.005

Edible bird's nest (EBN) is the nest of the swift that is made from its saliva. Although EBN has been widely used for enhancing immunocompetence, its antiviral efficacy has not been studied in detail. We found that EBN extract could strongly inhibit infection with influenza viruses in a host range-independent manner when it was hydrolyzed with Pancreatin F. Western blotting assay showed that the EBN extract bound to influenza virus. Furthermore, EBN extract could neutralize the infection of MDCK cells with influenza viruses and inhibit hemagglutination of influenza viruses to erythrocytes, but it could not inhibit the activity of influenza virus sialidase. Fluorometric HPLC indicated that the major molecular species of sialic acid in EBN is N-acetylneuraminic acid. The results suggest that EBN is a safe and valid natural source for the prevention of influenza viruses.