Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell

• Published in: Cell adhesion & migration Vol. 17; no. 1; pp. 1 - 13
• Main Authors: Fuselier, Camille, Dufay, Eleonore, Berquand, Alexandre, Terryn, Christine, Bonnomet, Arnaud, Molinari, Michael, Martiny, Laurent, Schneider, Christophe
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2023; Taylor & Francis Group
• Subjects: cancer; Cell Membrane; dynamized ultra-low dilution; Humans; Melanoma; Melanoma, Cutaneous Malignant; migration; Plant Extracts - pharmacology; plasma membrane; Research Paper; Ruta; Skin Neoplasms; migration; dynamized ultra-low dilution; cancer; plasma membrane; Melanoma
• ISSN: 1933-6918; 1933-6926; 1933-6926
• DOI: 10.1080/19336918.2022.2154732

Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology.