The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity

TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TF...

Full description

Saved in:
Bibliographic Details
Published inMolecular & cellular oncology Vol. 4; no. 6; p. e1372867
Main Authors Rao, Lang, Sha, Youbao, Eissa, N. Tony
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 02.11.2017
Taylor & Francis Group
Subjects
Author's View
Autophagy
CHIP
proteasome
STUB1
TFEB
ubiquitin
TFEB
proteasome
STUB1
CHIP
Autophagy
ubiquitin
Online AccessGet full text

Cover

More Information
Summary:TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin proteasome pathway. Thus, the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2017.1372867