Clinical Characteristics of Ocular Sarcoidosis: A Population-Based Study 1976-2013

• Published in: Ocular immunology and inflammation Vol. 27; no. 3; pp. 389 - 395
• Main Authors: Ungprasert, Patompong, Tooley, Andrea A., Crowson, Cynthia S., Matteson, Eric L., Smith, Wendy M.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2019
• Subjects: Adult; Age Distribution; Aged; Aged, 80 and over; Cohort study; epidemiology; Eye Diseases - epidemiology; Eye Diseases - etiology; Female; Follow-Up Studies; Forecasting; granuloma; Humans; Incidence; Male; Middle Aged; Minnesota - epidemiology; Population Surveillance; Prevalence; Retrospective Studies; sarcoidosis; Sarcoidosis - complications; Sarcoidosis - epidemiology; Sex Distribution; uveitis; Minnesota; epidemiology; sarcoidosis; uveitis; Cohort study; granuloma
• ISSN: 0927-3948; 1744-5078
• DOI: 10.1080/09273948.2017.1386791

Purpose: To characterize the epidemiology and clinical characteristics of ocular involvement in patients with systemic sarcoidosis. Methods: An inception cohort of patients with systemic sarcoidosis in 1976-2013 in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Medical records of those patients were then reviewed for ocular involvement. Results: A total of 345 incident cases of systemic sarcoidosis were identified. Ocular involvement occurred in 23 patients (7%). The most common ocular disease was uveitis (61%) followed by dry eye disease, conjunctival nodule, episcleritis, anterior scleritis, and conjunctivitis. Anterior uveitis was the most common type of uveitis (71%). The visual outcome of uveitis was favorable with only one patient lost three or more lines of VA during follow-up and had VA of less than 20/200 at last visit. Conclusion: Ocular involvement occurred in 7% of sarcoidosis patients. Uveitis was the most common type of ocular disease.