Three-membered ring amides — a calculational and conceptual study of the structure and energetics of 1,2-oxaziridine-3-one and aziridine-2,3-dione

• Published in: Canadian journal of chemistry Vol. 93; no. 4; pp. 406 - 413
• Main Authors: Miranda, Margarida S, Ferreira, Paulo J.O, Esteves da Silva, Joaquim C.G, Liebman, Joel F
• Format: Journal Article
• Language: English
• Published: Ottawa NRC Research Press 01.04.2015; Canadian Science Publishing NRC Research Press
• Subjects: Amides; Biochemistry; Chemical compounds; Chemical properties; Chemical reactions; cyclopropane and cyclopropanone derivatives; Cyclopropane compounds; Diketones; dérivés du cyclopropane et de la cyclopropanone; enthalpie de formation; enthalpy of formation; Experiments; Identification and classification; Mathematical analysis; molecular structure and energetics; molécules organiques contraintes; Organic compounds; strained organic molecules; structure moléculaire et énergétique
• ISSN: 0008-4042; 1480-3291
• DOI: 10.1139/cjc-2014-0321

Species with three-membered rings and the amide linkage are well studied. A quick perusal of the literature with SciFinder finds some 50 000 references to cyclopropanes and almost 300 000 references to amides. In the current paper, we discuss the structure and energetics of two understudied three-membered ring amides, 1,2-oxaziridine-3-one ( 5 ) ( simultaneously describable as the simplest cyclic carbamate and simplest hydroxamate) and aziridine-2,3-dione ( 7 ) (simultaneously describable as the simplest imide and simplest α-ketoamide), with but 5 and nearly 10 references, respectively, for these two classes of compounds. Neither 1,2-oxaziridine-3-one ( 5 ) nor aziridine-2,3-dione ( 7 ), nor any derivative thereof, has been isolated. Calculational theory ameliorates the paucity of experimental information. The current study reports our computational findings for these and related species (e.g., enols and imidols) where we have used the G3(MP2)//B3LYP method.