Myeloperoxidase, a possible biomarker for the early diagnosis of cardiac diastolic dysfunction with preserved ejection fraction

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 33; no. 1; pp. 1292 - 1298
• Main Authors: Coculescu, Bogdan Ioan, Dincă, Gabi Valeriu, Bălăeţ, Constantin, Manole, Gheorghe, Bălăeţ, Maria, Stocheci, Cristina Mariana
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2018; Taylor & Francis Group
• Subjects: Biomarkers - blood; Biomarkers - chemistry; Biomarkers - metabolism; diastolic dysfunction (DD); Dose-Response Relationship, Drug; Early Diagnosis; Echocardiography; Female; Heart Failure, Diastolic - diagnosis; Humans; left ventricle ejection fraction (LVEF); Male; Molecular Structure; Myeloperoxidase (MPO); Peroxidase - blood; Peroxidase - chemistry; Peroxidase - metabolism; preserved systolic function (PRESYF); reactive oxygen species (ROS); Research Paper; Structure-Activity Relationship; left ventricle ejection fraction (LVEF); Myeloperoxidase (MPO); reactive oxygen species (ROS); preserved systolic function (PRESYF); diastolic dysfunction (DD)
• ISSN: 1475-6366; 1475-6374
• DOI: 10.1080/14756366.2018.1499626

The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) with preserved systolic function caused by a painful chronic ischaemic cardiopathy - angina pectoris stable at the effort. The diagnosis was established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all patients and then these values were correlated with some of the echocardiography parameters that proved the mentioned diagnosis. In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function. The use of the MPO increased circulating levels as a biomarker for diagnosis and risk due to the statistically significant correlation between those and the results of the other two aforementioned paraclinical investigation.