Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis

• Published in: Translational oncology Vol. 58; p. 102419
• Main Authors: Wu, Wenjie, Xie, Youxi, Jiang, Cheng, Jiang, Xiaobing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2025; Neoplasia Press; Elsevier
• Subjects: Glioma; Pathogenesis; Review; TRIM proteins; Ubiquitination; TRIM proteins; Ubiquitination; Glioma; Pathogenesis
• ISSN: 1936-5233; 1936-5233
• DOI: 10.1016/j.tranon.2025.102419

•This review integrates prior studies with TCGA database analysis to evaluate the prognostic significance and genetic features of TRIM proteins in gliomas.•This review explores the upstream mechanisms regulating TRIM protein expression in gliomas and summarizes their differential expression between gliomas and normal brain tissue.•This review systematically classifies the roles of TRIM proteins in glioma progression, distinguishing between E3 ubiquitin ligase-associated and independent functions, offering a framework for future research.•This review summarizes advancements in drug development targeting TRIM proteins and discusses the potential and challenges of their clinical application in glioma therapy. Gliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for developing novel and effective treatment strategies. In recent years, increasing attention has been directed toward the tripartite motif (TRIM) family of proteins, a class of E3 ubiquitin ligases, due to their significant roles in glioma development and progression. This review comprehensively explores the diverse functions of TRIM proteins in gliomas, including their expression patterns, prognostic significance, and mechanisms of action that are both ubiquitination-dependent and -independent. By synthesizing current knowledge, we aim to elucidate the role of TRIM proteins in glioma pathogenesis and identify potential therapeutic targets within this protein family. [Display omitted]