Cellular mechanisms underlying adult tissue plasticity in Drosophila

• Published in: Fly (Austin, Tex.) Vol. 16; no. 1; pp. 190 - 206
• Main Authors: Nagai, Hiroki, Miura, Masayuki, Nakajima, Yu-ichiro
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: Adaptation, Physiological; Adult tissue plasticity; Animals; brain; Cell Differentiation; dedifferentiation; Drosophila - physiology; Drosophila melanogaster; Drosophila melanogaster - genetics; Homeostasis - physiology; midgut; nutrient response; polyploidy; regeneration; Review; stem cell; testes; polyploidy; stem cell; regeneration; nutrient response; testes; midgut; dedifferentiation; Adult tissue plasticity; brain; Drosophila melanogaster
• ISSN: 1933-6934; 1933-6942
• DOI: 10.1080/19336934.2022.2066952

Adult tissues in Metazoa dynamically remodel their structures in response to environmental challenges including sudden injury, pathogen infection, and nutritional fluctuation, while maintaining quiescence under homoeostatic conditions. This characteristic, hereafter referred to as adult tissue plasticity, can prevent tissue dysfunction and improve the fitness of organisms in continuous and/or severe change of environments. With its relatively simple tissue structures and genetic tools, studies using the fruit fly Drosophila melanogaster have provided insights into molecular mechanisms that control cellular responses, particularly during regeneration and nutrient adaptation. In this review, we present the current understanding of cellular mechanisms, stem cell proliferation, polyploidization, and cell fate plasticity, all of which enable adult tissue plasticity in various Drosophila adult organs including the midgut, the brain, and the gonad, and discuss the organismal strategy in response to environmental changes and future directions of the research.